DERIVATIVES OF SULFONYLUREA OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, A METHOD OF THEIR SYNTHESIS AND A PHARMACEUTICAL COMPOSITION BASED ON DERIVATIVES OF SULFONYLUREA SHOWING ANTITUMOR ACTIVITY Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of sulfonylurea of the formula: A-S(O)₂-NH-C(O)-NH-Ph(R²)(R³), where A - 2,3-dihydro-1H-indolyl or IR¹-indolyl; R¹ is C₁-C₆-alkyl; R² and R³ mean independently each of other - H, halogen, C₁-C₆ - alkyl, trifluoromethyl at condition that only one of substituents R² and R³ can be hydrogen. These derivatives are used in a pharmaceutical composition showing antitumor activity. Compounds are synthesized by interaction of compound Y-Ph(R²)(R³) with sulfonyl compound of the formula: A-S(O)₂-X where Y is NH₂ or NCO; X is NCO, NH₂ or NHCOO-R^a where R^a is C₁-C₃-alkyl at condition that if X means NCO or NHCOO-R^a then Y is NH₂; if X is NH₂ then Y is NCO. EFFECT: improved method of synthesis, enhanced antitumor effectiveness of compounds. 8 cl, 1 tbl, 7 ex