DERIVATIVES OF QUINOXALINE, METHOD OF THEIR SYNTHESIS AND AN AGENT SHOWING QUISQUALATE-ANTAGONISTIC EFFECT BASED ON THEREOF Russian patent published in 1998 - IPC

EFFECT: organic chemistry and technology. SUBSTANCE: products: derivatives of quinoxaline of the formula (I) R¹ where R² is a group substituted by residue : -alkyl, -alkenyl or alkynyl, (CH₂)_n-cycloalkyl or R²-phenyl; R³ - CO-R² or POXY being R⁴ can be occurred one or two time only; R¹, R⁵- R⁸ - H or NR⁹R¹⁰ are similar or distinct: hydrogen, halogen, nitro-group, group R¹¹, NHCO-CF₃, cyano-group, , -alkyl, R³-alkoxy or imidazole; n = 0-5; - hydroxyl, NR⁹R¹⁰-alkoxyl or ; X and Y - hydroxyl, -alkoxyl, NR⁹R¹⁰-alkyl or R⁹; R¹⁰ and - H, R¹¹-alkyl; - R¹ ,R⁵ ,R⁶ ,R⁷-alkyl. Reagent 1: compound of the formula (II) R⁸ where R^4, and R^4, have values indicated for compounds of the formula (I) which is subjected for cyclization reaction with reactive derivative of oxalic acid and if necessary the formed compound is treated with compound R⁴-X where X - halogen, tosylate, mesylate and triphthalate. has values except for hydrogen. Synthesized compounds can be used in medicine as drugs for treatment of patients with central nervous system disorders. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 5 cl, 1 tbl, 12 ex