FIELD: organic synthesis. SUBSTANCE: invention provides novel 1,4-fihydropyridine derivatives of general formula I: 
, wherein R1 is phenyl, which is unsubstituted or substituted by 1 to 6 identical or different residues from the group consisting of nitro, halogen, and trifluoromethyl; R2 and R3, identical or different, are C1-C8-alkyl or C1-C8-alkoxy; a = 1, 2 or 3; R4 is methyl; or R3 and R4 together represent alkylene -CH2-CH2-CH2- or alkylene -CH2-C(CH3)2-CH2-; in the form of mixture of their isomers. Compounds I show selectivity for Ca- dependent high-conductivity potassium canals. EFFECT: expanded assortment of useful biologically-active compounds. 4 cl, 4 tbl, 19 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 1-ALKYL-3,5-DIALYL-1,4-DIHYDROPYRIDINE DERIVATIVES AS MIXTURE OF ISOMERS THEREOF | 1995 |
|
RU2158259C2 |
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| DERIVATIVES OF 1,4-DIHYDROPYRIDINE, MIXTURES OF THEIR ISOMERS OR SEPARATE ISOMERS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND 2-CHLORO-3-CYANOBENZALDEHYDE | 1994 |
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