FIELD: organic chemistry, steroids. SUBSTANCE: invention describes a new compound of the formula (I)
: 17β-N-(2,5-bis-(trifluoromethyl)-phenylcarbamoyl-4-aza-5α-androst-1-ene-3-one as a very strong and selective dual inhibitor of human 17β-reductase of type 1 and 2. Invention describes also a method of its synthesis, a pharmaceutical composition based on the above indicated compound and a method of treatment of patients. EFFECT: improved method of synthesis, enhanced effectiveness of the compound. 7 cl, 1 tbl, 4 ex
Title |
Year |
Author |
Number |
ANDROSTEN(ANE) (ONE) DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SOLVATE THEREOF, METHODS OF PREPARATION THEREOF, AND METHOD OF MEDICAL TREATMENT |
1994 |
- Behchelor Kennet Uil'Jam
- Fraj Stiven Vernon
|
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|
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- Filippe L.D'Jurette
- Uil'Jam K.Khagmann
- Tomas Dzh.Lantsa
- Soumia P.Sakhoo
- Gari Kh.Rasmusson
- Richard L.Tolman
- Derek Von Langen
|
RU2142956C1 |
INHIBITORS OF TESTOSTERONE 5α-REDUCTASE, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF TESTOSTERONE 5α-REDUCTASE ACTIVITY |
1993 |
- Fernand Labri
- Iv Meran
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|
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FLUORINATED DERIVATIVES OF 17β-SUBSTITUTED-4-AZA--5α-ANDROSTANE- -3-ONE, PHARMACEUTICAL COMPOSITION |
1993 |
- Akille Pantseri
- Marchella Nesi
- Ehnriko Di Salle
|
RU2125061C1 |
METHOD OF TREATMENT OF PATIENTS WITH PROSTATE BENIGNITY HYPERPLASIA, PHARMACEUTICAL PREPARATION CONTAINING INHIBITOR OF 5-ALPHA-REDUCTASE |
1992 |
- Glenn Dzh.Gomlej
- Ehlizabet Stoner
|
RU2125879C1 |
HALOGEN- AND PSEUDOHALOGEN-SUBSTITUTED 17-METHYLENE-4-AZASTEROIDS, THEIR USING, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION |
2002 |
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ANTIANDROGENIC COMPOUNDS, PRECURSOR OF ANTIANDROGENIC COMPOUND, PHARMACEUTICAL COMPOSITIONS |
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- Shankar M.Singkh
|
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INDOLE DERIVATIVES |
1994 |
- Kugola Al'Fredo
- Di Fabio Romano
- Pentassul'Ja Dzhordzhio
|
RU2144535C1 |
METHOD OF PREPARING 7β--SUBSTITUTED 4-AZA -5α- ANDROSTAN- 3-ONES AND METHOD OF PREPARING SUBSTITUTED 7β- ALKYL ANDROST-5-EN-3-ONES |
1993 |
- Raman K.Bakshi
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|
RU2114117C1 |