FIELD: organic chemistry, steroids. SUBSTANCE: invention describes a new compound of the formula (I)
: 17β-N-(2,5-bis-(trifluoromethyl)-phenylcarbamoyl-4-aza-5α-androst-1-ene-3-one as a very strong and selective dual inhibitor of human 17β-reductase of type 1 and 2. Invention describes also a method of its synthesis, a pharmaceutical composition based on the above indicated compound and a method of treatment of patients. EFFECT: improved method of synthesis, enhanced effectiveness of the compound. 7 cl, 1 tbl, 4 ex
| Title |
Year |
Author |
Number |
| ANDROSTEN(ANE) (ONE) DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SOLVATE THEREOF, METHODS OF PREPARATION THEREOF, AND METHOD OF MEDICAL TREATMENT |
1994 |
- Behchelor Kennet Uil'Jam
- Fraj Stiven Vernon
|
RU2144037C1 |
| METHOD OF TREATMENT OF ANDROGEN ALOPECIA WITH 5-ALPHA-REDUCTASE INHIBITORS |
1994 |
- Glenn Dzh. Gomli
- Kejt D. Kaufman
- Ehlizabet Stoner
- Dzhoann Val'Dshtrajkher
|
RU2173152C2 |
| 16-SUBSTITUTED 4-AZAANDROSTANES, COMPOUNDS, METHODS OF INHIBITION, PHARMACEUTICAL COMPOSITION |
1994 |
- Filippe L.D'Jurette
- Uil'Jam K.Khagmann
- Tomas Dzh.Lantsa
- Soumia P.Sakhoo
- Gari Kh.Rasmusson
- Richard L.Tolman
- Derek Von Langen
|
RU2142956C1 |
| INHIBITORS OF TESTOSTERONE 5α-REDUCTASE, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF TESTOSTERONE 5α-REDUCTASE ACTIVITY |
1993 |
- Fernand Labri
- Iv Meran
- Shankar M.Singkh
|
RU2141967C1 |
| FLUORINATED DERIVATIVES OF 17β-SUBSTITUTED-4-AZA--5α-ANDROSTANE- -3-ONE, PHARMACEUTICAL COMPOSITION |
1993 |
- Akille Pantseri
- Marchella Nesi
- Ehnriko Di Salle
|
RU2125061C1 |
| METHOD OF TREATMENT OF PATIENTS WITH PROSTATE BENIGNITY HYPERPLASIA, PHARMACEUTICAL PREPARATION CONTAINING INHIBITOR OF 5-ALPHA-REDUCTASE |
1992 |
- Glenn Dzh.Gomlej
- Ehlizabet Stoner
|
RU2125879C1 |
| HALOGEN- AND PSEUDOHALOGEN-SUBSTITUTED 17-METHYLENE-4-AZASTEROIDS, THEIR USING, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION |
2002 |
- Mentsenbakh Bernd
- Dresher Peter
- Khillish Aleksander
- Ehl'Ger Val'Ter
- Shvajkert Khans-Udo
- Shell'Kopf Klaus
|
RU2293740C2 |
| ANTIANDROGENIC COMPOUNDS, PRECURSOR OF ANTIANDROGENIC COMPOUND, PHARMACEUTICAL COMPOSITIONS |
1993 |
- Fernand Labri
- Iv Merand
- Shankar M.Singkh
|
RU2141966C1 |
| INDOLE DERIVATIVES |
1994 |
- Kugola Al'Fredo
- Di Fabio Romano
- Pentassul'Ja Dzhordzhio
|
RU2144535C1 |
| METHOD OF PREPARING 7β--SUBSTITUTED 4-AZA -5α- ANDROSTAN- 3-ONES AND METHOD OF PREPARING SUBSTITUTED 7β- ALKYL ANDROST-5-EN-3-ONES |
1993 |
- Raman K.Bakshi
- Gari Kh.Rasmusson
|
RU2114117C1 |
