FLUORINATED DERIVATIVES OF 17β-SUBSTITUTED-4-AZA--5α-ANDROSTANE- -3-ONE, PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, steroids, biochemistry, pharmacy. SUBSTANCE: invention relates to fluorinated derivatives of 17β-substituted-4-aza--5α- -androstane-3-one of the general formula (I) where B is a bond; R is H, alkyl; 17β is H, alkyl optionally substituted with one or more fluorine atoms or benzyl group; -5α is H, F, alkyl possibly substituted with F, phenyl or benzyl; R₁ is H, F,alkyl, possibly substituted F, or phenyl; R₂ is H, F, when Y - a double bond then A is H, F, alkyl possibly substituted with one or more fluorine atoms; when Y - a single bond then A is hydrogen or a group R₃ where R₄ and mean independently hydrogen or alkyl possibly substituted with one or more fluorine atoms; A is R₆, R₇. Invention proposes also a pharmaceutical composition containing a compound (I) as an active component that inhibits activity of testosterone-R₈- -reductase. EFFECT: improved method of synthesis, enhanced effectiveness of composition. 6 cl, 1 tbl, 12 ex