PHOSPHINIC ACID ESTERS OR THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION BASED ON ABOVE COMPOUNDS, AND METHOD FOR CORRECTION OF DISTURBANCES IN METABOLIC PROCESSES IN BRAIN Russian patent published in 1999 - IPC

FIELD: pharmaceutical chemistry. SUBSTANCE: invention relates to new phosphinic acid esters having general formula I: (I), wherein X is halogen, C₁-C₄-alkyl, or di-C₁-C₄-alkylamino group; h=0-3; Y halogen or di- C₁-C₄-alkylamino group; n'= 1-4; R¹ and R² are hydrogen atoms or, together, =NOH group; R³ and R⁴, independently, hydrogen, optionally substituted C₁-C₄-alkoxy group, 2,2,2-trichloro-1-hydroxyethyl, acetyl, or, together, =CHR″′ or =CH-CH=CHR″′ where R″′ is C₁-C₄-alkyl or phenyl optionally substituted by OH, COOH or nitro groups, and to their physiologically acceptable salts. Compounds I are prepared by interaction of hydrazine with phosphorylacetic acid ester. Compounds I exhibit high neotropical and antidepressive activity. Invention also relates to pharmaceutical composition exhibiting neotropical and antidepressive activity and containing, as active principle, compound I in effective amount. Therapeutically active dose of compound I is used for correction of metabolic processes in brain. EFFECT: expanded possibilities in correction of brain activity. 19 cl, 4 dwg, 13 tbl, 14 ex