SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-a]PYRIMIDINE-2,6-DIAMINES, SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS OF PRODUCING AND USING SAID COMPOUNDS Russian patent published in 2011 - IPC C07D487/04 A61K31/519 A61K9/48 A61K9/08 A61P25/28 A61P25/16 A61P25/18 A61P25/24 A61P3/06 

FIELD: chemistry.

SUBSTANCE: invention relates to novel substituted 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidine-2,6-diamines of general formula 1, their pharmaceutically acceptable salts and/or hydrates which have serotonin 5-HT₆ receptor antagonist properties and can be used in treating or preventing development of various central nervous system diseases, whose pathogenesis is associated with 5-HT₆ receptors, particularly Alzheimer's disease, Parkinson's disease, Huntington disease, schizophrenia, other neurodegenerative diseases, cognitive and anxiety disorders and obesity. In general formula (I): R¹, R² and R⁴, which are optionally identical, independently denote C₁-C₃ alkyl; R³ and R⁴, which are optionally identical, denote: a hydrogen atom, optionally substituted C₁-C₃ alkyl or acetyl; R⁵ denotes a hydrogen atom or halogen atom.

EFFECT: high treatment efficiency.

13 cl, 12 dwg, 4 tbl, 12 ex