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2 142 009

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IPC

(21) (22)

Application

97115504/13, 1997-09-15

(24)

Start date

1997-09-15

(22)

Actual filing date

1997-09-15

(45)

Published

1999-11-27

(72)

Inventor

Seroglazov V.V.Kozhukhov V.V.Strochkov Ju.I.Amosov M.Ju.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Mikrobiologii Ministerstva Oborony Rossijskoj Federatsii

METHOD OF MAINTENANCE OF ANTHRAX VACCINE STRAIN STI-1 Russian patent published in 1999 - IPC

Abstract RU 2142009 C1

FIELD: medicine, microbiology. SUBSTANCE: invention relates to the production of stable vaccine antianthrax preparations of the high quality. Microbic population is passaged through the body of susceptible animal, analyzed culture is sown on an agar medium containing an antianthrax globulin. Medium ensures to detect toxin-forming clones. Clones are detected under the full value control of the most immunologically important determinants pag, lef, cya by method of polymerase chain reaction. Invention ensures to obtain homogeneous and high-immunogenic cultures by indices of toxin formation determinants from heterogeneous cultures of the vaccine strain STI-1 of decreased immunogenicity and to prevent possible increase of dissociation of properties of cultures at frequent resowing under nonselective conditions. EFFECT: improved method of maintenance. 3 tbl, 4 ex

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RU 2 142 009 C1

Authors

Seroglazov V.V.

Kozhukhov V.V.

Strochkov Ju.I.

Amosov M.Ju.

Dates

1999-11-27—Published

1997-09-15—Filed