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IPC

C12N1/21(2006-01-01)

C12P21/00(2006-01-01)

C12R1/07(2006-01-01)

(21) (22)

Application

2006122774/13, 2006-06-26

(24)

Start date

2006-06-26

(22)

Actual filing date

2006-06-26

(45)

Published

2008-04-10

(72)

Inventor

Mikshis Natal'Ja IvanovnaPopov Jurij AlekseevichShulepov Dmitrij Viktorovich

(73)

Holder

Federal'Noe Gosudarstvennoe Uchrezhdenie Zdravookhranenija Nauchno-Issledovatel'Skij Protivochumnyj Institut Federal'Noj Sluzhby Po Nadzoru V Sfere Zashchity Prav Potrebitelej I Blagopoluchija Cheloveka

ASPOROGENOUS RECOMBINANT STRAIN Bacillus anthracis 55ΔТПА-1Sро (pUB110РА-1) AS PRODUCER OF ANTHRAX MICROORGANISM ANTIGEN Russian patent published in 2008 - IPC C12N1/21 C12P21/00 C12R1/07

Abstract RU 2321629 C1

FIELD: biotechnology, microbiology.

SUBSTANCE: invention relates to the asporogenous recombinant strain B. anthracis 55ΔTPA-1Spo^- (pUB110PA-1) producing the anthrax microorganism protective antigen that is obtained by transformation of the strain B. anthrax 55ΔTSpo^- with DNA of hybrid plasmid pUB110PA-1. The strain is deposited in GK of pathogenic "Mikrob" at number KM-97, and this the strain is characterized by absence of ability for spores formation, stability of hybrid replicon and high level of production of the protective antigen that represents the main component of chemical anthrax vaccines.

EFFECT: valuable biological of strain.

9 ex

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RU 2 321 629 C1

Authors

Mikshis Natal'Ja Ivanovna

Popov Jurij Alekseevich

Shulepov Dmitrij Viktorovich

Dates

2008-04-10—Published

2006-06-26—Filed