FIELD: pharmacy. SUBSTANCE: medicinal form has from 0.1 to 15 mg of alprazolam, from 0.1 to 80 mg water-soluble carriers and/or water-insoluble carriers, from 0.01 to 15 mg nonionic surface-active substance exhibiting the value of hydrophilic-lipophilic index from 13 to 18 and disintegrating agent at concentration from 2 to 20%. Water-soluble carriers are alpha-, beta- and gamma-cyclodextrins, mono-, di-, oligo- and polysaccharides or polyvinylpyrrolidone of an average molecular mass from 25 000 to 120 000 Da. Water-insoluble carriers are porous and nonporous silicon dioxide, titanium dioxide and aluminium oxide. Disintegrating agent is taken among starch glycolate sodium, cross-linked polyvinylpyrrolidone and cross-linked sodium carboxymethylcellulose. To prepare the solid medicinal form alprazolam is applied on the surface of indicated carrier from solution in the presence of nonionogenic surface-active substance and disintegrating agent. Water and/or an organic solvent at boiling point below 100 C under the normal atmospheric pressure is used as a solvent. The novel medicinal form provides the rapid and stable release of alprazolam from the medicinal preparation being the rate and pattern of dissolving are not depend on physical indices of the parent form of alprazolam. EFFECT: improved form of the medicinal form. 3 cl, 1 dwg, 2 ex
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