METHOD OF SYNTHESIS OF 2-[2,4-DIFLUOROPHENYL]-1,3-BIS-[1H-1,2,4-TRIAZOLE-1-YL]-PROPANE- 2-OL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 2001 - IPC

Abstract RU 2170736 C2

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes method of synthesis of 2-[2,4-difluorophenyl]-1,3-bis-[1H-1,2,4-triazole-2-ol (fluconazol) and its pharmaceutically acceptable salts. Method involves interaction of compound of the formula (IV) where R is hydrogen atom and Z is triazole with s-triazine. Fluconazol is an antifungal agent. Method ensures to prevent formation of nondesirable by-side products. EFFECT: improved method of synthesis, increased yield. 2 cl, 4 dwg, 25 ex

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RU 2 170 736 C2

Authors

Al'Berto Palomo Koll

Dates

2001-07-20—Published

1996-12-20—Filed