FIELD: organic chemistry, pharmacology. SUBSTANCE: invention proposes a new antagonist of tachykinin binding with tachykinin receptors. Invention relates to the known antiestrogen of the formula (I): 
where R1 and R3 mean independently hydrogen atom, methyl, 
or 
where Ar is optionally substituted phenyl; R2 is taken among the group involving pyrrolidine group and piperidine group; or its pharmaceutically acceptable salts. EFFECT: broadened arsenal of agents. 4 cl, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| NONPEPTIDE ANTAGONISTS OF TACHIKININ RECEPTORS | 1994 |
|
RU2140921C1 |
| (R)-3-(1H-INDOLE-3-YL)-1-[N-(2-METHOXYBENZYL)ACETYLAMINO]-2- -[N-(2-(4-PIPERIDINE-1-YL)PIPERIDINE-1-YL)ACETYL)AMINO]PROPANE DIHYDROCHLORIDE TRIHYDRATE AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2151769C1 |
| METHOD FOR INHIBITING NEUROPEPTIDE γ | 1995 |
|
RU2188015C2 |
| AGENT FOR INHIBITION OF MAMMAE PATHOLOGICAL STATE | 1994 |
|
RU2126251C1 |
| METHOD OF INHIBITION OF STATES ASSOCIATED WITH BRADYKININ | 1995 |
|
RU2181047C2 |
| AGENT FOR INHIBITION OF OXIDATION OF LOW DENSITY LIPIDS AND ATHEROSCLEROSIS SUPPRESSION | 1994 |
|
RU2127592C1 |
| USE OF 2-PHENYL-3-AROYLBENZOTHIOPHENES FOR SERUM BLOOD CHOLESTEROL DECREASE, PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2150275C1 |
| USE OF 2-PHENYL-3-AROYLBENZOTHIEPHENES, THEIR SALTS OR SOLVATES FOR INHIBITION OF OSSEOUS TISSUE LOSS, PHARMACEUTICAL COMPOSITION CONTAINING 2-PHENYL-3-AROYLBENZOTHIEPHENES AND THEIR SALTS OR SOLVATES | 1995 |
|
RU2100024C1 |
| USE OF 2-PHENYL-3-AROYLBENZOTHIOPENES FOR INHIBITION OF THROMBOTIC DISORDER AND FOR ENHANCEMENT OF PROTEIN C ACTIVATION | 1994 |
|
RU2190405C2 |
| AGENT FOR INHIBITION OF NEUROTOXICITY CAUSED BY BETA-AMYLOID PEPTIDES | 1994 |
|
RU2128992C1 |
