FIELD: medicine, more particularly antidepressive duloxetine agent in the form of intestinal granules. SUBSTANCE: granule consists of nucleus comprising duloxetine and pharmaceutically acceptable filler, optionally separating layer, intestinal layer comprising hydroxypropylmethyl cellulose acetate-succinate and pharmaceutically acceptable filler, and optionally completing layer. Duloxetine granules are stable during storage period. Agent passes uncharged through stomach and rapidly separates out duloxetine in thin intestines. EFFECT: improved properties of the title granules. 10 cl, 11 ex
