FIELD: organic chemistry. SUBSTANCE: product: derivatives of indole of the formula (I) 
where: R1 - H, C1-C4-alkyl, cyclopropylmethyl, phenyl-substituted C1-C4-alkyl; R2 - H, C1-C4-alkyl, cyclopropylmethyl; R3 - H or amine-blocking group; A - C=O; R7-C1-C8-alkyl, CF3, aryl, substituted aryl, and its pharmaceutically acceptable salts. Empirical formula is C22H22H32N2O, m. p. is 92 C. Reagent 1: compound of the formula (I) 
where: R7-A″ - Li; R3 - K. Reagent 2: R7C(O)X where X - halide. Synthesized compounds show capability for selective binding with 5-hydroxytryptamine (serotonine) receptors and can be used in medicine. EFFECT: improved method of synthesis. 8 cl, 2 tbl
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Year |
Author |
Number |
| 6-HETEROCYCLIC SUBSTITUTED 4-AMINO-1,2,2A,3,4-HEXAHYDROBENZ-[CD]-INDOLES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND METHOD FOR THEIR PRODUCTION |
1992 |
- Richard Nolan Bukher[Us]
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- Charl'Z Dzhonson Pehjdzhet
- Dzhon Menert Skaus[Us]
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1993 |
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1991 |
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0 |
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1992 |
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1994 |
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1993 |
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