FIELD: medicine, therapy, pharmacology. SUBSTANCE: invention relates to method of modulation and/or reproduction of effects of endogenous production of cytokines and hemopoietic factors and/or induction of apoptosis mechanisms. Method involves administration of effective amount of oxidized glutathione or its pharmaceutically acceptable derivative in mammalian organism needing with stimulation of cytokines or hemopoietic factors for time that is sufficient for modulation of endogenous production of cytokines and hemopoietic factors to obtain therapeutic effect. Indicated oxidized glutathione and/or its pharmaceutically acceptable salts and/or pharmaceutically acceptable derivatives are administrated by parenteral or topical route. Oxidized glutathione and/or its pharmaceutically acceptable salts and/or pharmaceutically acceptable derivatives are administrated in combination with prolongator of indicated oxidized glutathione half-life and/or its pharmaceutically acceptable salts and/or its pharmaceutically acceptable derivatives half-life. EFFECT: broadened spectrum of agents for regulation of production of cytokines and hemopoietic factors. 56 cl, 7 dwg, 48 tbl, 27 ex
Authors
Dates
2000-07-27—Published
1996-12-10—Filed