PALLADIUM-COPPER CATALYSTS FOR HOMOGENEOUS SELECTIVE OXIDATION OF THIOL GROUPS, COMBINATION AND COMPOSITION BASED ON SAID CATALYSTS AND THERAPEUTIC TREATMENT METHOD Russian patent published in 2012 - IPC C07C319/24 A61K31/95 A61K31/28 A61K31/30 A61P31/12 A61P7/04 B01J31/16 B01J23/89 

FIELD: chemistry.

SUBSTANCE: palladium-copper catalyst for homogeneous selective oxidation of thiols combines a functional binuclear thiolate bridge coordination compound of palladium (II) and a modifying thiolate complex of copper (I), having general formula [pd₂ ^II(µ-SR)₂(NH₃)₄]·{Cu¹ _k(SR)_m} (I). SR is a residue of a thiolate ligand of glutathione or acetylcysteine, k ranges from 2 to 14, m≥3k. The invention also discloses a catalytic combination which stimulates proliferative activity, a pharmacological combination for enhancing therapeutic activity of a purine and(or) pyrimidine base or lithium ions, pharmaceutical compositions which stimulate proliferative activity, and for enhancing therapeutic activity of said bases or lithium ions, and methods for therapeutic treatment of a patient based on said catalyst.

EFFECT: catalyst has low toxicity and can be used in pharmacological solutions with medicinal agents for therapy of different duration where catalytic activity is needed in reactions for oxidative modification of thiols to disulphides in peptide molecules.

19 cl, 3 dwg, 11 tbl, 12 ex