FIELD: pharmaceutics.
SUBSTANCE: group of inventions relates to pharmaceutical industry, namely to pharmaceutical composition (and its use) for eliminating dose-related toxicity and increasing the therapeutic activity of a pharmacologically active compound in treatment of infectious and non-infectious diseases, glutathione disulphide or a pharmaceutically acceptable organic or inorganic salt thereof and a glutathione disulfide S-oxide or a pharmaceutically acceptable organic or inorganic salt thereof; as well as a pharmacological combination (and its use) comprising said composition and a pharmacologically active compound selected from an anticoagulant, a factor Xa inhibitor, an antimicrobial or antiviral agent, a calcium channel inhibitor; to a medicament comprising a therapeutically effective amount of said composition or combination together with pharmaceutically acceptable excipients.
EFFECT: group of inventions provides reduction of dose-dependent toxicity and the enhancement of the effectiveness of various pharmacotherapeutically active agents.
23 cl, 14 ex, 7 tbl, 6 dwg
