FIELD: medicine, traumatology, orthopedics. SUBSTANCE: before endoprosthesis 0.3 ml of venous blood is taken in patient, blood is centrifuged and buffer (pH is 7.2-7.4) is added to sediment up to volume 1.5 ml. Obtained suspension is divided for 5 equal parts followed by addition of 0.3 ml of 2.2-% hydrogen peroxide solution to the first part, 48 mcl of 1-% methylmethacryalte solution to the second part and 96 mcl of 1-% methylmethacrylate solution to the third part. Then all samples are incubated at 37 C for 1 h. Saponin 4-% solution is added to the fifth sample 10 min before termination of incubation up to complete hemolysis of erythrocytes. Samples are centrifuged and obtained supernatant liquid is subjected for photometry at λ = 414 nm and the percent content (A) of hemolyzed erythrocytes is calculated in the first three samples by the formula: A = 
x 100 where a is mean extinction of the 1-st, 2-d and 3-d samples; b is extinction of the 5-th sample; c is extinction of the 4-th sample. If A1 is less 4.1%, A2 is less 1.6%, A3 is less 2.5% than prognosis is considered to be favorable; if A1 is above 5.1%, A2 is above 2.2%, A3 is above 6% than prognosis is considered to be unfavorable; at intermediate values of A1, A2 and A3 a patient is concerned to the risk group. Method provides detection of implantation syndrome risk development in preoperative period. EFFECT: improved method of prognosis. 1 dwg, 2 ex
