PHARMACEUTICAL COMPOSITION FOR IMPROVEMENT OF CEREBRAL CIRCULATION AND METHOD OF ITS PREPARING Russian patent published in 2000 - IPC

Abstract RU 2155039 C1

FIELD: medicine, pharmacy. SUBSTANCE: pharmaceutical composition has the following components, mas.pts.: vinpocetine as an active substance, 1.0; starch, 4.1-12.4; lactose, 6.8-24.8; aerosil, 0.1-1.64; and stearic acid salt, 0.05-0.2, as pharmaceutically acceptable accessory substances. Composition is made as tablet preferably. Method of preparing the pharmaceutical composition involves mixing vinpocetine with vehicle, wetting obtained mass with starch paste, wet granulation, drying, dry granulation, addition of aerosil and stearic acid salt followed by tabletting. Mixture of starch and lactose is used as vehicle in mass ratio = 1:(1.40-2.04), respectively. Mass ratio of starch paste and wetting mass = 1:(2.5-3.9). Starch paste has 2.0-8.0 wt.% of starch. Remained mass of starch is added in vehicle composition. New composition releases active substance vinpocetine easily. EFFECT: stability in storage, high bioavailability, decreased adverse effect, enhanced effectiveness. 5 cl, 1 tbl, 4 ex

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RU 2 155 039 C1

Authors

Tjuljaev I.I.

Jurchenko N.I.

Bykov V.A.

Demchenko B.I.

Zuev A.P.

Dates

2000-08-27Published

1999-12-14Filed