FIELD: medicine, urology, pharmacy. SUBSTANCE: antibacterial agent is made as the solid medicinal form that consists of core and envelope. Core has nitroxoline as an active component and aerosil, starch, lactose and slipping substances as special additions. Core has the following components, wt. -%: nitroxoline, 38.0-62.0; aerosil, 1.0-10.0; starch, 12.0-30.0; lactose, 12.0-30.0; slipping substances, 1.0-4.0. Envelope consists of sugar, magnesium base carbonate, aerosil, talc, titanium dioxide, polyvinylpyrrolidone, dye and polishing substances. Method of agent making involves wetting mixture of active component with special additions and slipping substances, granulation, drying, dry granulation, core formation and application of envelope on core by layers. Envelope layers have sugar, magnesium base carbonate, aerosil, talc, titanium dioxide, polyvinylpyrrolidone and mixture of sugar, dye and polishing substances in series. Preparation shows stability and releases the active component in gastroenteric tract rapidly. Invention can be used for treatment of patients with infections of urogenital ways (pyelonephritis, cystitis, prostatitis) and prophylaxis of infections after surgery in kidney and urinary ways. EFFECT: enhanced effectiveness of agent, improved method of preparing. 7 cl, 1 tbl, 4 ex
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Authors
Dates
2000-05-27—Published
1999-09-09—Filed