METHOD OF SYNTHESIS FURAN SULFONEAMIDE COMPOUNDS USED IN SYNTHESIS OF NEW INHIBITORS OF INTERLEUKIN-1 Russian patent published in 2000 - IPC

Abstract RU 2155760 C1

FIELD: organic chemistry. SUBSTANCE: invention describes the novel effective method of synthesis of furam sulfoneamide compounds of the formula (I) involving interaction of compound of the formula (II) in reaction inert solvent with methylated Grignard's reagent where R' means (C₁-C₆)-alkyl. Compounds of the formula (I) are used as intermediate substances with isocyanate compounds to yield sulfonyl derivates of urea that are useful inhibitors of interleukin-1α and interleukin-1β used for treatment of patients with central nervous system diseases. EFFECT: simplified method of synthesis. 15 cl, 7 ex

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RU 2 155 760 C1

Authors

Urban Frank Dzhon

Dzhejsis Vitautas Dzhon

Dates

2000-09-10—Published

1999-07-26—Filed