SULFONAMIDES, METHOD OF THEIR SYNTHESIS Russian patent published in 2003 - IPC

Abstract RU 2197479 C2

FIELD: organic chemistry, chemical technology, biochemistry. SUBSTANCE: invention relates to novel derivatives of sulfonamides of the general formula (I) where R1 means being each of a, b and c = 1; each of A1, A2, A3 is taken independently among hydrogen atom, (C1-C5)-alkyl, phenyl or substituted phenyl; R2 and R3 are taken independently among (C1-C6)-alkyl; or R2 and R3 form in common 3-7-membered cycloalkyl, tetrahydropyrane-4-yl ring or bicyclic ring of the formula: where asterisk means carbon atom that is general for R2 and R3; Q means (C1-C6)-alkyl, (C6-C10)-aryl, (C6-C10)-aryl-(C1-C6)-alkyl, (C6-C10)-aryloxy-(C1-C6)-alkyl, (C6-C10)-aryloxy-(C6-C10)-aryl, (C6-C10)-aryl-(C6-C10)-aryl, (C6-C10)-aryl-(C6-C10)-aril-(C1-C6)-alkyl, (C6-C10)-aryl--aryl-(C6-C10)-aryl, (C6-C10)-aryl-(C1-C6)-alkyl or (C6-C10)-aryl-(C1-C6)-alkoxy-(C6-C10)-aryl where each (C6-C10)-aryl group of indicated (C6-C10)-aryl, (C6-C10)-aryl-(C1-C6)-alkyl, (C6-C10)-aryloxy-(C1-C6)-alkyl, (C6-C10)-aryloxy-(C6-C10)-aryl, (C6-C10)-aryl-(C6-C10)-aryl, (C6-C10)-aryl-(C6-C10)-aryl-(C1-C6)-alkyl, (C6-C10)-aryl-(C6-C10)-aryl-(C6-C10)-aryl, (C6-C10)-aryl-(C1-C6)-alkyl or (C6-C10)-aryl-(C1-C6)-alkoxy-(C6-C10)-aryl is substituted possibly by any of ring carbon atom able to form additional bond, one or more substitute per a ring taken independently among fluorine, chlorine, bromine atom, (C1-C6)-alkyl, (C1-C6)-alkoxy-group, perfluoro-(C1-C3)-alkyl, perfluoro-(C1-C3)-alkoxy-group and (C6-C10)- aryloxy-group; and Y means hydrogen atom or -alkyl. Compounds of the formula (I) are intermediate substances used in synthesis of inhibitors of matrix metalloproteinases. EFFECT: improved method of synthesis, valuable biochemical properties. 12 cl

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RU 2 197 479 C2

Authors

Andresen Brajan Majkl

Khammen Filip Ditrich

Khokinz Dzhouehl Majkl

Dates

2003-01-27Published

1999-04-09Filed