INDOLE DERIVATIVES, SUBSTITUTED INDOLES, AND METHOD OF INHIBITING SEROTONIN 5HT RECEPTOR Russian patent published in 1999 - IPC

FIELD: medicine. SUBSTANCE: present invention describes indole derivatives of formula I: wherein Z is group of formula a) or b) ; R₁ is group of formula I (c), (d) or (e); X is -O-, NH or S; A, B, D, E and F each independently is C or N; R₂,R₃,R₄,R₅ and R₆ are H, C_1-6 alkyl, phenyl, alkylphenyl, halogen, cyano, nitro, -NR₇R₈, -SR₉, -SO₂R₉, -CONR₇R₈, -CO₂R₉;; or one or pairs R_2-6 taken together with ring carbon atoms to which they are attached form 5- or 6-membered heteroaryl ring containing 1 or 2 nitrogen heteroatoms; R₇ and R₈ are H, alkyl, phenyl, alkylphenyl, -(CH₂)_qR₁₀;; R₉ is alkyl, phenyl, alkylphenyl, hydrogen, -(CH₂)_wR₁₁;; R₁₀ and R₁₁ are OH, -OR₁₂, -CO₂R₁₂, -CONHR₁₂,, cyano; R₁₂ is H, alkylphenyl, phenyl, alkyl; R_13/ is H, -OR₁₄, -NHCOR₁₄;; R₁₄ is alkyl, alkylphenyl; n is 0,1 or 2; m is 1,2 or 3; q is 2,3 or 4; w is 2,3 or 4, said phenyl and phenyl moiety of alkylphenyl being optionally substituted by 1-3 substituents comprising C_1-4 alkyl, halogen, hydroxy, cyano, carboxamido, nitro, C_1-4 alkoxy; represents optional double bond, and pharmaceutically acceptable salts thereof. Compounds of formula I and pharmaceutical composition based on said compounds are potent serotonin (5-HT₁) agonists. Said compounds are useful for treating depression, fear, alimentary disorders, obesity, toxicomania, migraine and other disorders which result from deficient serotonergic neutrotransmission. EFFECT: improved properties of the herbicidal composition. 16 cl, 39 ex, 2 tbl