FIELD: organic chemistry. SUBSTANCE: derivatives of dihydropyridine of the general formula (I) 
where: R1 - free aryl with 6-10 carbon atoms or one-three-fold substituted with similar or different substituents taken from the group involving halogen atom, nitro-group, cyano-group, trifluoromethyl, trifluoromethoxy-group and trifluoromethylthio-group; or substituted with direct or branched alkyl with 1-8 carbon atoms that is free or substituted with aryl with 6-10 carbon atoms, or substituted with direct or branched alkoxy-group or alkoxycarbonyl with 1-8 carbon atoms, carboxy-group, amino-group, or the group of the formula -NR4R5, where: R4 and R5 are similar or different and mean hydrogen atom, direct or branched alkyl with 1-8 carbon atoms, phenyl or benzyl; or thienyl; R2- - hydrogen atom or cycloalkyl with 5-8 carbon atoms of direct or branched alkyl, alkenyl, alkadienyl or alkynyl with 1-10 carbon atoms, direct or one-two-substituted similar or different substituents from the group involving halogen atom, hydroxy-group, carboxy-group, cyano-group and nitro-group, or direct or branched alkylthio-group, alkoxy-group, alkoxycarbonyl, acyl or acylhydroxy-group with 1-8 carbon atoms, or cycloalkyl with 3-8 carbon atoms, phenoxy-group or phenyl being the latters are direct or one-two-substituted with similar or different substituents taken from the group involving halogen atom, direct or branched alkyl and alkoxy-group with 1-6 carbon atoms; or substituted with the group -NR4R5, where R4 and R5 have above indicated values; R3- - hydrogen atom or direct or branched alkyl with 1-8 carbon atoms; mixture of their isomers or their individual isomers and their physiologically tolerantable salts. Other objects of invention are method of synthesis of the indicated compounds, medicinal agent containing the indicated substances and method of its preparing. EFFECT: improved method of synthesis. 7 cl, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
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