FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula 
(I), where A is C-R1b; R1a, R1b, R1c, R1d, R1e, R2, R3, R4, R5 and n are as described in claim 1 of the invention, as well as pharmaceutically acceptable salts thereof. Described also is a pharmaceutical composition having activity as glucocorticoid receptor modulators.
EFFECT: novel compounds are obtained and described, which are glucocorticoid receptor antagonists and useful for treating and/or preventing diseases such as diabetes, dyslipidaemia, obesity, hyptension, cardiovascular diseases, adrenal gland malfunction or depression.
24 cl, 210 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF THIOPHEN AND PHARMACEUTICAL COMPOSIITON (VERSIONS) | 2003 |
|
RU2359967C2 |
| HETEROCYCLIC COMPOUNDS POSSESSING ELASTASE-INHIBITORY ACTIVITY AND THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITION AND AGENT BASED ON THEREOF | 2003 |
|
RU2319708C2 |
| TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS TNF ACTIVITY MODULATORS | 2014 |
|
RU2684635C1 |
| METHOD OF RESIDUAL LIPOPROTEINS PRODUCING INHIBITION | 2004 |
|
RU2330682C2 |
| APPLYING COMPOUNDS FOR ENHANCING ACTIVITY OF PYRUVATE DEHYDROGENASE | 1999 |
|
RU2242224C2 |
| AMINOQUINAZOLINE COMPOUNDS | 2005 |
|
RU2382034C2 |
| FUNGICIDE BASED ON TRIAZOLPYRIMIDINE DERIVATIVES AND METHOD OF WOOD PRESERVATION | 2002 |
|
RU2335128C2 |
| PHARMACEUTICAL COMBINATIONS CONTAINING PYRIDO[4,3-d]PYRIMIDINE DERIVATIVES AS HSP90 INHIBITOR AND HER2 INHIBITOR | 2009 |
|
RU2532375C2 |
| NEW PHENYLAMIDE OR PYRIDYLAMIDE DERIVATIVES AND USING THEM AS GPBAR1 AGONISTS | 2009 |
|
RU2533887C2 |
| 1,3-DIARYL-SUBSTITUTED UREAS AS KINASE ACTIVITY MODULATORS | 2006 |
|
RU2402544C2 |
