FIELD: chemical industry. SUBSTANCE: method comprises treating rubomycin hydrochloride with hydrazine hydrate in methanol-chloroform and subsequently reacting the resulting hydrazone rubomycin hydrochloride with 2,2,6,6- tetramethyl-4-oxopiperidine-1-oxyl in the presence of 0.2-1.0% acetic acid. Prior to vacuum distillation of solvents, neutralizing agent is added to adjust pH of reaction mixture to 6.8-7.2. Method makes it possible to avoid acid hydrolysis of the desired product and prepare substance which is stable during storage period. EFFECT: more efficient preparation method. 2 cl, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| 13-(1-OXYL-2,2,6,6-TETRAMETHYLPIPERYLIDENYL-4)HYDRAZONE OF CHLORINE-HYDRATE RUBOMICIN WITH PARAMAGNETIC CENTER POSSESSING ANTITUMORAL ACTIVITY AND METHOD OF OBTAINING THE SAME | 1980 |
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| METHOD OF SYNTHESIS OF TETRAMETHYL-4-HYDROXY(AMINO)PIPERIDINES OR AMINODODECANOIC ACID LABELED WITH TRITIUM | 1986 |
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| NITROXYL DERIVATIVE OF AZIDO-DIDEOXYTHYMIDINE SHOWING ANTIVIRAL ACTIVITY | 1995 |
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SU435235A1 |
