NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED ON SAID AND METHOD OF TREATMENT OR PROPHYLAXIS OF THROMBOTIC DISEASES Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes nitrogen-containing heterocyclic derivatives of the general formula (I) where A, B and C mean independently CH₂ or C=O; x and y are different and each means CH or W; D means -(CH₂)_k or -(CH₂)_m-CO- where k is the whole number from 1 to 4; m is the whole number from 0 to 3; E means the group (II) or (III) where n is the whole number from 1 to 3 and Z means W-(CH₂)_p-COOR³ where W means -O- or bond; p is the whole number from 1 to 4; R³ is hydrogen atom, lower alkyl; R¹ is hydrogen atom or lower alkyl substituted with 2-oxodioxol-4-yl; R² is hydrogen atom, and their pharmaceutically acceptable salts and solvates showing ability to inhibit platelet aggregation. Invention describes pharmaceutical composition based on the above indicated compounds and method of treatment or prophylaxis of thrombotic diseases using compounds of the formula (I). EFFECT: improved method of treatment and prophylaxis, valuable medicinal properties. 14 cl, 1 tbl, 16 ex