PHARMACEUTICAL COMPOSITION, DERIVATIVES OF TRITERPENE Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to pharmaceutical compositions inhibiting hepatocytes necrosis based on derivatives of triterpene of the general formula (I) where R¹ means OH, C_1-6-alkoxy-, C_1-6-alkylcarbonyloxy- or benzyloxy-group; R²- means C_1-6-alkyl, CH₂OR⁵ where R⁵- means H, C_1-6-alkyl, benzyl or C_1-6-alkylcarbonyl, formyl, COOR⁶ where R⁶ means H or C_1-6-alkyl or -CH₂N(R⁷)R⁸ where R⁷ and R⁸ are similar of different and mean H or C_1-6-alkyl; or R¹ and R² form in common -O-CR⁹(R¹⁰)-OCH₂- where R⁹ and R¹⁰ are similar or different and mean H or C_1-6-alkyl or phenyl; R³ and R⁴ are similar or different and mean H, OH, C_1-6-alkyl, hydroxy-C_1-6- alkyl, formyl, -COOR¹¹ where R¹¹ means H or OR¹² where R¹² means C_1-6-alkyl, benzyl, C_1-6-alkylcarbonyl, phenylcarbonyl, C_2-6- alkenyl, C_2-6-alkenylcarbonyl or phenylalkenylcarbonyl; or R³ and R⁴ form in common =CH or = O group; means an ordinary or double bond under condition that when is a double bond then R⁴ is absent. Compounds are able to inhibit necrosis of hepatocytes that can be used in treatment of liver diseases. EFFECT: valuable medicinal properties of compounds and composition. 37 cl, 1 tbl, 65 ex