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2 159 811

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Application

99111221/13, 1999-05-25

(24)

Start date

1999-05-25

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Actual filing date

1999-05-25

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Published

2000-11-27

(72)

Inventor

Kiseleva I.V.Aleksandrova G.I.Rudenko L.G.Naumenko Z.S.Klimov A.I.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

INFLUENZA VIRUS STRAIN A/17/PEKING/95/25 (H1N1) FOR PRODUCTION OF LIVE INFLUENZAL INTRANASAL VACCINE FOR ADULTS Russian patent published in 2000 - IPC

Abstract RU 2159811 C1

FIELD: applied microbiology. SUBSTANCE: vaccinal strain A/17/Peking/95/25 (H1N1), which is reassortant, is obtained by cross-breeding of epidemic virus A/Peking/262/95 (H1N1) with cold-adapted temperature-sensitive virus A/Leningrad/134/47/57 (H2N2), which is attenuation donor. The strain is harmless for adults. It actively multiplies in developing chicken embryos at optimal temperature 33-34 C and is characterized by temperature sensitivity and cold adaptability. Reassortant inherits two genes from epidemic virus, which encode surface proteins (gemmagglutinin and neuraminidase). Six genes received from attenuation donor encode non-glycosylated proteins. The strain does non induce immune response in adults during intranasal injection. Biological properties and low degree of immunoreactivity meet Pharmacopoeia requirements for vaccine strains of live influenzal vaccine for intranasal administration for adults. EFFECT: reliably enabled isolation of reassorted vaccinal strains from newly appearing epidemic viruses. 1 tbl

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RU 2 159 811 C1

Authors

Kiseleva I.V.

Aleksandrova G.I.

Rudenko L.G.

Naumenko Z.S.

Klimov A.I.

Dates

2000-11-27—Published

1999-05-25—Filed

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