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2 159 812

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Application

99112368/13, 1999-06-15

(24)

Start date

1999-06-15

(22)

Actual filing date

1999-06-15

(45)

Published

2000-11-27

(72)

Inventor

Kiseleva I.V.Aleksandrova G.I.Rudenko L.G.Naumenko Z.S.Klimov A.I.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

INFLUENZA VIRUS STRAIN A/17/SYDNEY/97/76 (H3N2) FOR PRODUCTION OF LIVE INFLUENZAL INTRANASAL VACCINE FOR ADULTS Russian patent published in 2000 - IPC

Abstract RU 2159812 C1

FIELD: applied microbiology. SUBSTANCE: vaccinal strain A/17/Sydney/97/76 (H3N2), which is reassortant, is obtained by cross-breeding of epidemic virus A/Sydney/5/97/ (H3N2) with cold-adapted temperature-sensitive virus A/Leningrad/134/17/57 (H2N2), which is attenuation donor. Strain A/17/Sydney/97/76 (H3N2) actively multiplies in developing chicken embryos at optimal temperature 33-34 C. Strain is characterized by temperature sensitivity and cold adaptability. Reassortant inherits two genes from epidemic virus, which encode surface proteins (gemmagglutinin and neuraminidase). It also receives six genes encoding non-glycosylated proteins from attenuation donor. Low degree of immunoreactivity of the strain meet requirements for strains for live influenzal vaccine for intranasal administration for adults. EFFECT: enabled prophylactics of epidemic influenza provoked by specific antigenic virus species. 1 tbl

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RU 2 159 812 C1

Authors

Kiseleva I.V.

Aleksandrova G.I.

Rudenko L.G.

Naumenko Z.S.

Klimov A.I.

Dates

2000-11-27—Published

1999-06-15—Filed

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