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2 159 810

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Application

99111220/13, 1999-05-25

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Start date

1999-05-25

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Actual filing date

1999-05-25

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Published

2000-11-27

(72)

Inventor

Kiseleva I.V.Aleksandrova G.I.Rudenko L.G.Naumenko Z.S.Klimov A.I.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

INFLUENZA VIRUS STRAIN A/47/PEKING/95/35 (H1N1) FOR PRODUCTION OF LIVE INFLUENZAL INTRANASAL VACCINE FOR BABIES Russian patent published in 2000 - IPC

Abstract RU 2159810 C1

FIELD: applied microbiology. SUBSTANCE: vaccinal strain A/47/Peking/95/35 (H1N1), which is reassortant, is obtained by cross-breeding of epidemic virus A/Peking/262/95 (H1N1) with cold-adapted temperature-sensitive virus A/Leningrad/134/47/57 (H2N2), which is attenuation donor. The strain is harmless for babies. It actively multiplies in developing chicken embryos at optimal temperature 33-34 C and is characterized by temperature sensitivity and cold adaptability. Reassortant inherits two genes from epidemic virus, which encode surface proteins (gemmagglutinin and neuraminidase), and six genes from attenuation donor encoding non-glycosylated proteins. In addition, the strain does non induce immune response in babies during intranasal injection. EFFECT: reliably enabled isolation of reassorted vaccinal strains from newly appearing epidemic viruses. 1 tbl

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RU 2 159 810 C1

Authors

Kiseleva I.V.

Aleksandrova G.I.

Rudenko L.G.

Naumenko Z.S.

Klimov A.I.

Dates

2000-11-27—Published

1999-05-25—Filed

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