NARROW POLY-AND MONO-DISPERSED WATER-SOLUBLE OLIGOMER, METHOD OF PREPARING THEREOF, PHARMACEUTICAL AGENT AND METHOD OF INHIBITING ACTIVITY OF VIRUSES Russian patent published in 2000 - IPC

Abstract RU 2160746 C2

FIELD: medicine. SUBSTANCE: described is narrow poly-and mono-dispersed water- soluble oligomer which has polydispersity ratio from 1.0 to 1.3 and is polyurea of formula I: wherein R is hydrogen atom, C1-C4 alkyl group, phenyl group or phenyl group substituted by 1 to 2 fragments of R1 and having up to 3 substituents independently selected from chlorine or bromine atoms or C1-C4 alkyl groups; R1 is SO3R2, -CO2R2, -PO3(R2)2 or -OPO3R2; R2 is hydrogen atom or pharmaceutically acceptable cation; m is integer of 0 or 1 provided that if m is O, R is hydrogen atom, X is aromatic substituent which is defined in claim 1, Y is CO2-, -C=C-, -N=N- or (a) n is integer of 3-15, and R3 is R or -X-NH2, wherein R and X are as defined above. Compounds have biological activity against virus of human immunodeficit. Also described are pharmaceutical agent based thereon, method of preparing oligomer, method of inhibiting activity of viruses. EFFECT: improved properties of the pharmaceutical agent, and more efficient inhibition method. 27 cl, 15 dwg, 6 ex, 3 tbl

Similar patents RU2160746C2

Title Year Author Number
WATER SOLUBLE OF RIGID-CHAIN OLIGOMER - OLIGOUREA AND METHOD FOR ITS PRODUCTION 1991
  • Alan D.Karden[Us]
  • Richard L.Dzhekson[Us]
  • Majkl Dzh.Mallins[Us]
RU2099360C1
WATER-SOLUBLE RIGID-CHAIN POLYAMIDE OLIGOMER, METHOD OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION 1992
  • Karden Alan D.[Us]
  • Dzhekson Richard L.[Us]
  • Mallins Majkl Dzh.[Us]
RU2102406C1
WATER-SOLUBLE STRONG-CHAIN OLIGOESTER, METHOD OF ITS SYNTHESIS AND COMPOSITION BASED ON THEREOF 1992
  • Alan D.Karden[Us]
  • Richard L.Dzhekson[Us]
  • Majkl Dzh.Mallins[Us]
RU2108345C1
COMPLEXES OF METALS WITH BICYCLOPOLYAZAMACROCYCLE, METHOD OF THEIR SYNTHESIS AND A PHARMACEUTICAL COMPOSITION USED FOR TREATMENT OF PATIENTS WITH CANCER 1992
  • Gehrri E.Kifer
  • Dzhejm Sajmon
RU2118325C1
METHOD OF POLYMER PREPARING 1990
  • Richard E.Kehmpbell
RU2011654C1
SUBSTITUTED MONOCYCLOPENTADIENYL METALLIC COMPLEX, METHOD OF PREPARATION THEREOF, AND METHOD OF PREPARING ETHYLENE (CO)POLYMERS 1990
  • Dzhejms S.Stivenz[Us]
  • Dehvid R.Nitejmer[Us]
RU2095363C1
METAL CHELATES COMPRISING LIGANDS OF 3-ARYL-SUBSTITUTED INDENYL, CATALYST OF OLEFIN POLYMERIZATION AND METHOD OF POLYMERIZATION 1997
  • Nikias Piter N.
  • Patton Dzhesson T.
RU2186073C2
METHOD OF PREPARING ETHYLENE-ALPHA OLEFIN COPOLYMER COMPOSITION AND ETHYLENE-ALPHA OLEFIN COPOLYMER COMPOSITION 1994
  • Brajan V.S. Koltammer
  • Robert S.Kadvell
RU2113443C1
METHOD OF PREPARING EMULSIONS HAVING HIGH CONTENT OF INTERNAL PHASE, AND LATEXES BASED THEREON 1996
  • Dzhejms E. Pehjt Iii
  • Nanett E. Lutenske
  • Dzhejms Peters
  • Ronal'D R. Pellet'Er
RU2163244C2
OLEFIN POLYMERIZATION CATALYST ACTIVATOR, CATALYTIC SYSTEM, AND POLYMERIZATION PROCESS 1997
  • Rouzen Robert K.
  • Vanderlende Dehniehl D.
RU2178422C2

RU 2 160 746 C2

Authors

Alan D. Karden

Uill'Jam A. Fordajs

Majkl Dzh. Mallins

Tomas Chemberlin

Majkl Dzh. Fazio

Dates

2000-12-20Published

1993-01-07Filed