COMPLEXES OF METALS WITH BICYCLOPOLYAZAMACROCYCLE, METHOD OF THEIR SYNTHESIS AND A PHARMACEUTICAL COMPOSITION USED FOR TREATMENT OF PATIENTS WITH CANCER Russian patent published in 1998 - IPC

Abstract RU 2118325 C1

FIELD: organic chemistry, complex compounds. SUBSTANCE: invention proposes complexes of bicyclopolyazamacrocyclophosphonic acid with metal ions, in part, with 153-Sm, 177-Lu, 159-Gd, 149-Pm, 140-La, 175-Yb, 166-Ho, 90-Y, 47-Sc, 186-Re, 188-Re, 142-Pr, 99m-Tc, 67-Ga, 68-Ga, 105-Ru, 111-In, 113m-In or 115m-In. Complexes are bound covalently with biologically active molecule, for example, antibody or its fragment leading to conjugate formation. Obtained complexes and conjugate are benefit for using as radiopharmaceutical preparations for treatment and/or diagnosis. Invention proposes methods of synthesis of these compounds also. EFFECT: improved method of synthesis, enhanced effectiveness of complexes.

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RU 2 118 325 C1

Authors

Gehrri E.Kifer

Dzhejm Sajmon

Dates

1998-08-27—Published

1992-12-10—Filed