DERIVATIVES OF AZOLE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, INTERMEDIATE COMPOUNDS Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of azole of the general formula (I) where R¹ and R² are similar or different and each means hydrogen atom, cycloalkyl and so on; or R¹ and R² form with (a) the condensed ring (b) or (c) that can be optionally substituted with lower alkyl, amino-group and so on; R³,R⁶,R⁷,R⁸ are similar or different and each means hydrogen atom and so on; R⁴ means cyano-group, tetrazolyl, -COOR⁹ and so on; R⁵ means hydrogen atom or lower alkyl; D means optionally substituted lower alkylene; X and Z are similar or different and each means oxygen or sulfur atom; Y means -N= or =CH=; A means -B-O-, -S-B-, -B-S- or -B- where B means lower alkylene or lower alkenylene; n = 2. Derivatives of azole of the general formula (I) or their pharmaceutically acceptable salts with pharmaceutically acceptable carrier form pharmcomposition showing activity of antagonist of leukotriene and antagonist of thromboxane A₂ that is useful for prophylaxis or treatment of allergic diseases, heart and brain ischemia. Intermediate compounds of the formula (IVc) and (IIIa) are given in the invention description. EFFECT: new compounds indicated above, valuable medicinal properties. 10 cl, 39 tbl, 156 ex