NOVEL AMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION PROMOTING INSULIN SECRETION AND ENHANCING SUSCEPTIBILITY TO INSULIN Russian patent published in 2002 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel amide derivatives of the general formula (I) or its salt where A means thiazolylene, imidazolylene, triazolylene, benzimidazolylene, benzothiazolylene, thiadiazolylene, imidazopyridylene or imidazothiazolylene; X means a bond, -NR⁵-, -NR⁵-CO-, -NR⁵-CONH-, NR⁵SO₂-, -NR⁵-C(= NH)NH-; R¹ means H, lower alkyl, aryl, pyridyl, thienyl, furyl, thiazolyl, benzimidazolyl, imidazopyridyl, triazolyl, thiadiazolyl, imidazolyl, imidazothiazolyl, benzothiazolyl, cyclohexyl that can be optionally substituted with halogen atom, lower alkyl, -OH, -CN, -NO₂,-CF₃,-NH₂, -O-lower alkyl and a substitute lower alkyl can be substituted with phenyl, naphthyl, furyl, thienyl or pyridyl; R^2a,R^2b mean H or lower alkyl; R³ means hydrogen atom or lower alkyl; R^4a,R^4b mean H or OH or taken in common they form groups =O or =N-O-lower alkyl; R⁵ means H or lower alkyl. Invention discloses also some particular compounds and a pharmaceutical composition promoting insulin secretion and enhancing the susceptibility to insulin. Invention can be used as a therapeutic agent for treatment of diabetes mellitus. EFFECT: new compounds indicated above, valuable medicinal properties. 6 cl, 30 tbl, 5 ex