FIELD: chemical-pharmaceutical industry and technology. SUBSTANCE: ondansetron hydrochloride dihydrate is prepared by mixing 3-[(dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carb- azole-4-one and 2-methylimidazole in medium of 55-65% aqueous dioxane in the presence of triethylamine at 33-42 C followed by mixture cooling and water addition. Obtained precipitate is filtered off, washed with water and suspended in 70-80% aqueous acetone followed by addition of hydrochloric acid and settling the reaction mixture for 0.5-1.5 h. Then acetone is added, precipitate is separated and dried at the room temperature. Obtained substance has crystals (size is less 90 mcm) being 95% of crystals have the size less 60 mcm. EFFECT: stable and pure product making. 8 cl, 2 tbl
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