ARYL- OR HETEROARYLAMIDES OF TETRAHYDRONAPHTHALENE-, CHROMAN-, THIOCHROMAN- AND 1,2,3,4-TETRAHYDROQUINOLINE CARBOXYLIC ACIDS SHOWING RETINOID-LIKE BIOLOGICAL ACTIVITY Russian patent published in 2001 - IPC

FIELD: organic chemistry. SUBSTANCE: invention describes novel compounds of the general formula (I) where X means S, O; X means [C(R₁)₂]_n where n = 0-2; R₁ means independently H or alkyl with 1-6 carbon atoms; R₂ means hydrogen atom or lower alkyl with 1-6 carbon atoms; R₃ means hydrogen atom or lower alkyl with 1-6 carbon atoms; m = 0-2; o = 0-4; p = 0-2; r = 0-2 under condition that when Z means O then sum of p means at least 1 and r means at least 1 and (W)_p is not a single alkyl group; Y means phenyl or pyridyl groups that may have one or two groups R₂ as a substituent; W means a substituent taken among the group consisting of F, Br, Cl, J, C_1-6-alkyl, fluorine-substituted C_1-6-alkyl, NO_2, N₃, OH, OCH₂OCH₃; L means -(C= Z)-NH- or HN-(C=Z); Z means O or S; A means (CH₂)_q where q = 0-5; B means COOH or its pharmaceutically acceptable salt, COOR₈ where R₈ means alkyl group with 1-10 carbon atoms. Compounds of the formula (I) show retinoid-like biological activity. EFFECT: valuable biological activity. 30 cl, 2 tbl