BIPHENYL DERIVATIVES AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS COMPRISING THEREOF Russian patent published in 2002 - IPC

FIELD: organic chemistry, cosmetics, pharmacy. SUBSTANCE: invention describes biphenyl derivatives substituted with aromatic or heteroaromatic radical and corresponding to the general formula (I): where: Ar means aromatic or heteroaromatic radical taken among: R₁; Z means atom S; -CH₂-OH, -OR₈ means or -COR₉; R₂ and R₃ taken in common form 6-membered ring optionally substituted with at least one methyl and/or optionally broken by oxygen or sulfur atom; R₄ means H, linear or branched C₁-C₂₀-alkyl, -OR₁₀ or polyester radical; R₅ means H, -OCOR₁₁, -OR₁₂, -(CH₂)_nCOR₁₃; n = 0-6, -O-(CH₂)_mOH; m = 1- 12, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, polyester radical or -CH₂- polyester radical, -O-(CH₂)_mCOR₁₃; R₆ means H or -OR₁₀; R₇ means H, linear or branched C₁-C₂₀-alkyl, -OR₁₀ or polyester radical; R₈ means H; R_9/ means H, -OR₁₄ or ; R₁₀ means H or lower alkyl; R₁₁ means lower alkyl; R₁₂ means H, linear or branched C₁-C₂₀-alkyl, mono- or polyhydroxyalkyl or optionally substituted aryl or aralkyl; R₁₃ means lower alkyl or -OR₁₀; R₁₄ means H, linear or branched C₁-C₂₀-alkyl; r′ and r″ that can be similar or different mean H, OH, lower alkyl, optionally substituted aryl; or r′ and r″ taken in common form heterocycle, as mixture of their isomers or salt of compounds of the formula (I) when R₁ means carboxyl group. Invention describes also pharmaceutical composition showing agonistic activity with respect to RAR and cosmetic composition for hair and body hygiene in humans inclined to the presence of acnes. Invention provides synthesis of novel compounds showing useful biological properties. EFFECT: valuable properties of compounds. 19 cl, 2 dwg, 1 tbl, 63 ex