HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF 5-LIPOXYGENASE ACTIVITY Russian patent published in 1999 - IPC

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention describes a new heterocyclic derivative of the general formula (I) or its pharmaceutically acceptable salts where Ar¹ means imidazolyl, pyrazolyl, 1,2,3- -triazolyl, 1,2,4-triazolyl that bound with X¹ by the ring nitrogen atom and can be optionally substituted with one or two C_1-4-alkyls; X¹ means a direct bond or C_1-4-alkylene; Ar² means phenylene optionally substituted with one or two halogen atom; X² means -A-X- or -X-A- where A means a direct bond or C_1-4-alkylene and X means hydroxy- or thio-group; Ar³ means phenylene optionally substituted with one or two substituents taken among halogen atom or cyano-group; R¹ and R² in common form the group of the formula -D¹-Z-D²- that in common with carbon atom to which it bound forms a ring having 3-8 atoms where D¹ and D² mean C_1-4-alkylene and Z means a direct bond, hydroxy-group or vinylene; D¹ and D² can be substituted with C_1-3-alkyl and Y means CONR³R⁴,CN,C(R³)=N-OR⁴,COOR³ or COR³ where R³ and R⁴ each means H or C_1-4-alkyl. Compounds of the formula (I) inhibit activity of enzyme 5-lipoxygenase and can be used for treatment or relief of inflammatory diseases, allergy and cardiovascular diseases in mammals. Invention describes also a pharmaceutical composition on the base of compounds of the formula (I) and a method of inhibition of activity of 5-lipoxygenase. EFFECT: valuable pharmacological and biochemical properties of compounds. 12 cl, 44 ex