SYNTHESIS AND ANTICANCER ACTIVITY OF DERIVATIVES OF ARYL AND HETEROARYL QUINOLINES Russian patent published in 2016 - IPC C07D215/22 C07D215/233 C07D215/38 C07D403/04 C07D405/14 C07D413/04 C07D413/14 C07D491/56 C07F9/60 C07F9/6558 C07F9/6561 A61K31/4709 A61K31/4741 A61P35/00 

Abstract RU 2584688 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula I and pharmaceutically acceptable salts thereof , where R is hydrogen, RO(OH)2, P(=O)(O-(C1-C6)alcylenphenyl)2 or P(=O)(OM)2; W represents 2-halogenphenyl, 3-halogenphenyl or 4-halogenphenyl; R5 is (C1-C6)alkoxy, hydroxyl or OR8; R6 is hydroxyl or (C1-C6)alkoxy; R7 represents hydrogen, hydroxyl or O-(C1-C6)alcylenphenyl; R8 represents a RO(OH)2, P(=O)(O-(C1-C6)alcylenphenyl)2 or P(=O)(OM)2, and m is monovalent metal ion; or where R is hydrogen, RO(OH)2, P(=O)(O-(C1-C6)alcylenphenyl)2 or P(=O)(OM)2; W represents 2-halogenphenyl, 3-halogenphenyl or 4-halogenphenyl; R5 represents hydrogen, (C1-C6)alkoxy, hydroxyl or OR8; R6 is (C1-C6)alkoxy; R7 is hydroxyl or O-(C1-C6)alcylenphenyl; R8 represents PO(OH)2, P(=O)(O-(C1-C6)alcylenphenyl)2 or P(=O)(OM)2, and m is monovalent metal ion. Disclosed compounds have anti-cancer activity. Invention also relates to compounds of formula I, radicals of which are presented in patent claim and to using pharmaceutical composition containing effective amount of compound of invention for treating cancer.

EFFECT: technical outcome is new compounds possessing anticancer activity.

17 cl, 23 dwg, 7 tbl, 4 ex

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RU 2 584 688 C2

Authors

Ko Shen-Chu

Li Ko-Khsyun

Khuan Li-Tszjau

Chou Li-Chen

U Tjan-Shun

Vej Ttszun-Der

Chun Tszin-Gun

Jan Dzhej-Syn

Khuan Chi-Khun

Tsaj Men-Tun

Dates

2016-05-20Published

2011-07-14Filed