ACYLATED AMINOALKYLIMIDAZOLES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2000 - IPC

Abstract RU 2152933 C2

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention describes acylated aminoalkylimidazoles of the general formula (I) where R₁ means phenyl group possibly monosubstituted with halogen atom or 1-naphthyl group; R₂ means hydrogen atom; or R₁ is hydrogen atom and R₂ is pyridyl or 2-(5-chloro)-pyridyl group; R₃ is halogen atom or C_1-4-alkoxy-group. Described compounds can be in free form or in the form of salts. Compounds of the formula (I) show capability to inhibit activity of 25-hydroxy-vitamin D₃ hydroxylase selectively. Invention describes also method of their synthesis and pharmaceutical composition based on compound of the formula (I). EFFECT: improved method of synthesis, valuable biochemical properties of compounds. 6 cl, 12 ex

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RU 2 152 933 C2

Authors

Shuster Ingeborg

Ehgger Khel'Mut

Dates

2000-07-20—Published

1995-05-16—Filed