NOVEL PYRIMIDINE AMIDE DERIVATIVES AND USE THEREOF Russian patent published in 2010 - IPC C07D401/04 A61K31/506 A61P35/00 A61P35/02 

FIELD: chemistry.

SUBSTANCE: present invention relates to novel substituted derivatives of N-(3-benzoylaminophenyl)-4-pyridyl-2-pyrimidine amine of general formula (I), with inhibitory activity towards protein kinase, method of producing said derivatives and pharmaceutical compositions based on the derivatives. In the compound of formula 1 R₁ is hydrogen and R₂ is NR₅R₆, or R₁ is NR₅R₆ and R₂ is hydrogen; R₃ is trifluoromethyl; R₄ is lower alkyl; and R₅ and R₆ are independently hydrogen, lower alkyl, di(lower alkyl)amino-lower alkyl, N-lower alkylpiperidinyl, N-lower alkylpyrrolidinyl, or lower alkyl, or NR₅R₆ together represent pyrrolidino, piperidino, morpholino, N-lower alkylpiperazino, 1N-imidazolyl, 1H-2-lower alkylimidazolyl, 1H-4-lower alkylimidazolyl or 1H-2,4-di-lower alkylimidazolyl, or a pharmaceutically acceptable salt of such a compound.

EFFECT: compounds can be used in treating diseases related to inhibition of protein kinase activity, such as neoplastic diseases or leukaemia.

13 cl, 21 ex