FIELD: synthesis of biologically-active compounds. SUBSTANCE: invention provides novel low-toxicity [4,5-b]quinolin and pyrimido[4,5-b]pyridin derivatives with formulas 1 and II: 
(I), 
(II) showing antimicrobial activity and exceeding by 12.8 times peorloxacin in activity and by 1280 times furacillin regarding colon bacillus. Compound I and II are prepared by condensation of 1-phenyl-2-methyl-6,7,8,9-tetrahydropyrinodo[4,5- b] quinolin-4-on and di-1-m-chlorophenyl-2-methyl-7,8-dihydro-6H- pyrimido[4,5-b]pyrimidin-4-on with 5-nitrofurfurol involving 2-methyl groups in pyrimidine cycles by way of heating reactants for 0.5 h in glacial acetic acid. EFFECT: increased assortment of antimicrobial agents. 1 tbl
| Title |
Year |
Author |
Number |
| 1-ARYL-7-METHYL-2-[β-(5'-NITRO-2'-FURYL)VINYL]-PYRIDO[2,3-D]- PYRIMIDINE-4-ONES SHOWING ANTIBACTERIAL ACTIVITY |
1999 |
- Gavrilov M.Ju.
- Novoselova G.N.
- Rudometova E.V.
- Kon'Shin M.E.
|
RU2148580C1 |
| 2-AMINO-5,6,7,8-TETRAHYDROQUINOLINE-3-CARBOXYLIC ACID 5-NITROFURFURYLIDENEHYDRAZIDE |
1998 |
- Gavrilov M.Ju.
- Novoselova G.N.
- Rudometova E.V.
- Kon'Shin M.E.
|
RU2136679C1 |
| QUINOLINO [2,1-b] QUINAZOLIN-12-ONE-5- CARBOXYLIC ACID CYCLOHEXYLAMIDE HAVING ANTIFLAVIRAL ACTIVITY |
1997 |
- Mikhalev A.I.
- Jushkov V.V.
- Jushkova T.A.
|
RU2130023C1 |
| 2-(4-CHLOROANILINO)-CINCHONNIC ACID ISOPROPYLAMIDE SHOWING AN ANTI-INFLAMMATORY AND ANALGETIC ACTIVITY |
1997 |
- Mikhalev A.I.
- Kon'Shin M.E.
- Zaks A.S.
- Zueva M.V.
- Vakhrin M.I.
|
RU2130018C1 |
| 2-CHLORO-5,6,7,8-TETRAHYDROQUINOLINE-4-CARBOXYLIC ACID 5-NITROFURFURYLIDENE HYDRAZIDE ELICITING AN ANTIBACTERIAL ACTIVITY |
1997 |
- Smirnova T.A.
- Gavrilov M.Ju.
- Novoselova G.N.
- Rudometova E.V.
- Kon'Shin M.E.
|
RU2127271C1 |
| N-BUTYLAMIDE 2-ANILINO-6,7-DIHYDRO-5H-PYRINDINE-3- CARBOXYLIC ACID HAVING ANTI-INFLAMMATORY ACTIVITY |
1997 |
- Galeeva R.N.
- Gavrilov M.Ju.
- Nazmetdinov F.Ja.
- Kolla V.Eh.
- Kon'Shin M.E.
|
RU2128651C1 |
| 6-NITRO-2-IMINOCOUMARIN 3-CARBOXYLIC ACID 4-TOLUIDIDE SILVER SALT ELICITING ANTIBACTERIAL ACTIVITY |
2003 |
- Ukhov S.V.
- Kon'Shin M.E.
- Novikova V.V.
- Odegova T.F.
- Syropjatov B.Ja.
|
RU2247119C1 |
| 5-ARYL-1-PHENYL-4-HETEROYL-3-HYDROXY-3-PYRROLINE-2-ONES ELICITING ANTIBACTERIAL ACTIVITY |
2003 |
- Gejn V.L.
- Gejn L.F.
- Platonov V.S.
- Voronina Eh.V.
|
RU2259369C2 |
| 5(3)-PHENYL-4-PHENYLAZO-3(5)-PYRAZOLE CARBOXYLIC ACID ELICITING ANTIBACTERIAL ACTIVITY |
2000 |
- Pimenova E.V.
- Khamatgaleev R.A.
- Voronina Eh.V.
- Solodnikov S.Ju.
- Anikina L.V.
|
RU2198165C2 |
| 2-OXO-1,2,5,6,7,8-HEXAHYDROQUINOLINE-4-CARBOXYLIC ACID ANILIDE SHOWING ANTI-INFLAMMATORY AND ANALGETIC ACTIVITY |
1999 |
- Smirnova T.A.
- Gavrilov M.Ju.
- Vasiljuk M.V.
- Zaks A.S.
- Kon'Shin M.E.
|
RU2154061C1 |
