FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to new 5-aryl-1-phenyl-4-heteroyl-3-hydroxy-3-pyrroline-2-ones of the formula:
wherein (1) X means sulfur atom (S); R means (CH3)2CH; (2) X means sulfur atom (S); R means (CH3)3C; (3) X means oxygen atom (O); R means (CH3)3C. Compounds of the formula (I) are prepared by interaction of the corresponding heteroylpyruvic acid methyl ester with mixture of aniline and aromatic aldehyde in acetic acid medium at short-time heating. Compounds elicit an anti-bacterial activity with value MIC = 3.9-7.8 mcg/ml as compared with 62-1000 mcg/ml for analogue.
EFFECT: valuable properties of compounds.
1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 4-ACETYL-3-HYDROXY-1-(2-HYDROXYETHYLAMINOETHYL)-5-PHENYL-3-PYRROLIN-2-ONE ELICITING ANTI-COAGULANT ACTIVITY | 2005 |
|
RU2312660C2 |
| 1-(3-AMINOPROPYL)-3-HYDROXY-5-(4-FLUOROPHENYL)-4-(4-CHLOROBENZOYL)-3-PYRROLINE-2-ONE HYDROCHLORIDE ELICITING ANTI-INFLAMMATORY ACTIVITY | 2004 |
|
RU2259354C1 |
| 4-ACETYL-5-(4-BROMOMETHYL)-3-HYDROXY-1-(3-HYDROXYPROPYL)-3-PYRROLIN-2-ONE, EXHIBITING NOOTROPIC ACTIVITY | 2008 |
|
RU2421446C2 |
| METHOD OF PRODUCING N-ARYLAMIDES OF AROLYLPIROINBURGATE ACIDS | 2014 |
|
RU2624226C2 |
| 5-(4-HYDROXYPHENYL)-4-(4-METHOXYBENZOYL)-3-HYDROXY-1-(2,2-DIMETHOXYETHYL)-3-PYRROLIN-2-ONE, EXHIBITING ANALGESIC AND ANTIPYRETIC PROPERTIES | 2009 |
|
RU2429229C1 |
| METHOD OF PREPARING 3-PYRROLINE-2-CABOXYLIC ACID DERIVATIVES | 1997 |
|
RU2199529C2 |
| 1,4,5,6-TETRAHYDRO-6-OXO-5-(2-PIPERAZINOETHYL)-4-PHENYL-3-(4-CHLOROPHENYL)PYRROLO[3.4-C]PYRAZOLE DIHYDROCHLORIDE ELICITING HYPOTENSIVE AND ANTI-COAGULANT ACTIVITY | 2006 |
|
RU2320661C2 |
| DERIVATIVE 4-AMINOMETHYL-6-BROMINE-5-HYDROXYINDOLE-3-CARBOXYLATE, METHODS OF THEIR OBTAINING (VERSIONS) AND THEIR APPLICATION | 2006 |
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| USE OF 5-ARYL-4-AROYL-3-HYDROXY-1-CARBOXYMETHYL-3-PYRROLIN-2-ONES AS ANALGESICS | 2023 |
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RU2816900C1 |
| QUINOLINE DERIVATIVES | 1999 |
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RU2197481C2 |
