NOVEL OPIOIDO-LIKE PEPTIDES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION Russian patent published in 2001 - IPC

FIELD: organic chemistry, peptides. SUBSTANCE: invention describes novel opioido-like peptides of the formula (I): X-R₁-R₂-R₃-R₄-N(Z)-Y, their salts, derivatives and analogues also where X is hydrogen atom; R₁ is Tyr; R₂ is D-Ala or D-Arg; R₃ is Phe(p-F); R₄ is Phe or Phe (p-F); Y and Z mean H. New compounds show analgetic activity of peripheral action and selectivity to subtype of μ-opioid receptors. Invention describes also method of their synthesis and pharmaceutical composition. EFFECT: new peptides indicated above, valuable pharmacological properties. 13 cl, 5 dwg, 1 tbl, 7 ex