TRIAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel compounds of triazole of the general formula (I) where A means linear or branched C₁-C₁₈-alkylene group that can include at least one group that is taken among O, S, CONH, COO, C₃-C₆-cycloalkylene or double or triple bond; B means radical of the formula (a) , (b) or (c) ; R¹ means H, NH₂, C₃-C₆-cycloalkyl or C₁-C₈-alkyl that can be free or substituted with O-C₁-C₈-alkyl; R² means H, OH, C₁-C₈-alkyl, C_3-6-cycloalkyl, CF₃, CN, WR³R⁴,SR³ or CO₂R³ where R³ means H or C₁-C₈-alkyl and R⁴ means H, C₁-C₈-alkyl or COR³ where R³⁴ means C₁-C₈-alkyl; Ar means naphthyl, phenyl with 1-2 substituents taken among C₁-C₈-alkyl, CF₃,CHF₂,NO₂,SR³,SO₂R³ where R³ means C₁-C₈-alkyl and also pyridyl, pyrimidyl or triazinyl that have from 1 to 3 substituents taken among C₁-C₈-alkyl, C₂-C₆-alkenyl, C₂-C_6/ -alkynyl, halogen atom, CN, CF₃,OR⁴ where R⁴ means hydrogen atom or C₁-C₈-alkyl, CO₂R³ where R³ means C₁-C₈-alkyl, phenyl that can be substituted with halogen atom, alkoxy- or phenoxy-group, C₃-C₆-cycloalkyl that can be condensed, phenylalkylamine or 5-membered aromatic heterocycle with 1-2 nitrogen atoms that can be condensed with benzene ring. Compounds show high affinity to dophamine-D₃-[sic] -receptors and therefore they can be used for treatment of patients with disorders giving responses for dophamine-D₃-ligands. Invention describes also pharmaceutical composition based on compounds of the formula (I). EFFECT: new compounds, valuable pharmacological properties. 11 cl, 9 tbl