FIELD: organic chemistry, heterocyclic compounds, purines, pharmacy. SUBSTANCE: invention relates to a derivative of purine L-nucleoside of the formula (I) 
where 
mean H; R2, R3, R5 mean OH; Z1 means N; Z2 is taken among N and CH; Z3 is taken among NR-, -C-(R)2, -S- where R are similar or different and taken among H, Br, NH2, alkyl and alkenyl; Z4 is taken among C=O, -NR-, -C-(R)2- where R are similar or different are taken among H and Br; Z5 means N; X is taken among H, OH, SH, -SNH2, -S(O)NH2, -S(O)2NH2; Y is taken among H and NH2; W means O; and if Y means NH2 then Z3 does not mean S-. Also, the invention describes the pharmaceutical composition containing the above indicated compounds. The proposed compounds and composition based on thereof show an immunomodulating activity. EFFECT: valuable medicinal properties of compounds and composition. 8 cl, 7 dwg, 30 ex
