HEPATITIS C VIRUS (HCV) ASIALOGLYCOPROTEIN, IMMUNOGENIC COMPOSITION, METHOD OF INDUCTION OF IMMUNE RESPONSE, METHOD OF IMMUNE ASSAY Russian patent published in 2001 - IPC

FIELD: medicine, virology. SUBSTANCE: invention relates to methods of diagnosis, prophylaxis and treatment of patients with hepatitis C. Two envepole proteins of hepatitis C (E1 and E2) are expressed without sialylation reaction. Recombinant expression of these proteins in lower eucaryotic organisms or in mammalian cells where therminal glycosylation is blocked results to producing recombinant proteins exhibiting large analogy with natural hepatitis C virus glycoproteins. If their are isolated by method based on their affinity to lectin GNA then proteins E1 and E2 are assembled to virus-like particles. Cells carrying mannose or asialoglycoprotein receptors can be used for infection hepatitis virus C and to use for virus culturing. EFFECT: improved method of induction and immune analysis. 6 cl, 4 ex