IMMUNOGENIC POLYPEPTIDE COMPOSITION, METHOD OF COMPOSITION PREPARING, METHOD OF PRODUCING AND METHOD OF ANTIBODY DETECTION, SET Russian patent published in 1999 - IPC

FIELD: biotechnology, immunology, virology. SUBSTANCE: composition has polypeptides from different isolates of hepatitis C virus and containing at least one epitope in variable domain of envelope polypeptide HCV E2/NS1 exhibiting an amino acid sequence 384-414 and/or one epitope in variable domain E1 exhibiting an amino acid sequence 215-255. Immunogenic composition is used for preparing antibodies against hepatitis C virus, detection of antibodies in sample, preparing immunogenic polypeptide compositions showing and cross-reactions with many isolates of hepatitis C virus. Invention ensures to make new diagnostics and vaccines. EFFECT: improved method of preparing, enhanced effectiveness of composition, improved method of producing and detection of antibodies. 18 dwg, 6 tbl, 7 ex