FIELD: biotechnology.
SUBSTANCE: invention relates to production of insulin analogues and can be used for recombinant production of human proinsulin and insulin with substitution of Glu(A14) in combination with additional modifications, including substitution in position B16 and/or B25 with a branched-chain amino acid.
EFFECT: invention enables to obtain an analogue of human proinsulin and insulin, having a reduced affinity of binding to insulin receptors.
9 cl, 3 tbl, 3 ex
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| HUMAN INSULIN ANALOGS, METHOD OF THEIR SYNTHESIS, INJECTION SOLUTION | 1986 |
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RU2823246C2 |
